Roadtrip with RVshare Fort Myers to Key West

On your Fort Myers to Key West RV road trip, you will have plenty of opportunities to enjoy the sandy beaches and spectacular sunshine of Florida. Fort Myers is home to beachside restaurants and historic homes. While in the area, you will not want to miss the chance to visit the islands of Sanibel and Captiva. If you love to collect shells, know that these islands are known for the unique specimens that wash up on the shores. Finally, you can kick back and relax at Key West, which is often called the "Capital of the Conch Republic." This lively island city is filled with spirited restaurants and bars that cater to both tourists and locals. 

Fort Myers to Key West Road Trip Itinerary

  • Trip Length: The drive will take about five and a half hours.
  • Mileage: It's 300 miles from Fort Myers to Key West.
  • Fun Fact: If you follow this Fort Myers to Key West road trip itinerary, you will travel on the Florida Keys Scenic Highway. It is the only highway in Florida to be designated as an "All-American Road" by the Federal Highway Administration.

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Nearby National Parks

During your Fort Myers to Key West road trip, you might want to visit the state's three national parks. These parks provide a perfect opportunity to stretch your legs and explore another side of Florida. Make sure to visit RVshare's national parks guide to get more details about these spectacular locations. 

Biscayne National Park

When traveling through the Miami area, you should spend a day at Biscayne National Park. This national park encompasses the islands, coral reefs, and shoreline mangrove forests in the northern part of the Florida Keys. It is only an hour's drive from downtown Miami, and you can see the cityscape from the park. Some of the park's islands and reefs are only accessible by boat, but there are plenty of rentals available for visitors. If you want to see the park's wildlife, visit Biscayne Bay Lagoon. Pelicans, dolphins, and turtles can all be found in this section of the park. The Maritime Heritage Trail is an underwater trail that links the most popular dive sites, including several shipwrecks. For some panoramic views of the coastline, you should head over to the Boca Chita Lighthouse. 

Everglades National Park  

Located on the southern tip of Florida, Everglades National Park covers over 1.5 million acres of wetlands. Sawgrass marshes, pine flatwoods, and coastal mangroves are all part of Everglades National Park. This park is home to several hundred animal species, including the Florida panther, West Indian manatee, and leatherback turtle. The park has been designated a UNESCO World Heritage Site, and it remains a popular spot for both visitors and locals. With its massive size, the park is known for its outdoor activities, such as hiking, camping, and boating. 

Dry Tortugas National Park

Once you reach Key West, you can visit another national park in the state. However, this 70-mile journey into the Gulf of Mexico can only be completed by seaplane or boat. Dry Tortugas National Park contains seven islands and a protected coral reef. If you want to spend time at the beach, you should visit Garden Key or the 19th-century Fort Jefferson. For those who want to explore under the waves, Loggerhead Reef is home to the Windjammer Wreck, which has become a popular diving site. Finally, bird lovers will want to check out Bush Key. This area is a nesting site for many native birds, including sooty terns.

Nearby State Parks

Florida is known for its beautiful natural landscapes. Spending a day at a state park is a great way to experience the best views of Florida. If you want to know more about these locations, check out our Florida state park guide

Silver Springs State Park

Silver Springs State Park dates back to the 1870s. In this park in Silver Springs, you can find the largest artesian spring in the country. If you want to take a unique look at the springs, make sure to purchase tickets for the famous glass-bottom boat tours. You can also take a kayak and explore over 5 miles of the Silver River. There is also a restored Florida Cracker Village and Museum on the grounds. 

Blue Spring State Park

Blue Spring State Park near Orange City is the largest spring on the St. Johns River. This state park is also a designated manatee refuge of the West Indian manatees. During the winter, the manatees will head to the warm waters of the spring. Snorkelers and swimmers can enjoy the 73-degree waters. However, swimming with the manatees is not permitted. The St. Johns River is a popular spot for boating, fishing, and canoeing. You can even take a boat tour of the park.

Bahia Honda State Park

Bahia Honda State Park is a tropical destination on one of Florida's more uninhabited keys. This state park is known for its magnificent sunsets, crystal-clear waters, and palm-lined beaches. You'll want to spend time on the beach and take in those balmy sea breezes. Snorkeling gear and kayaks are available to rent, and you can even book a boat trip to head off on a snorkeling excursion. If you want to see the local wildlife, make sure to visit the Sand and Sea Nature Center.

Along the Way

On this road trip from Fort Myers to Key West, you'll have the chance to visit some exciting points of interest in the Sunshine State. 

Edison and Ford Winter Estates

Fort Myers was home to the winter residences of Thomas Edison and Henry Ford. You should check out the 21-acre botanical garden on the grounds. Along with the winter homes, you can also visit the museum that features a few artifacts from these innovative men. 

Naples Pier

Plan a visit to the Naples Pier if you want to experience the true beauty of the Gulf of Mexico. Many people come to this location in Naples to get an undisturbed view of the white sandy beaches and blue Gulf waters. If you need any accessories for the beach, a concession stand and beach store are located on the pier. 

Ernest Hemingway House

Key West is known as the home of Ernest Hemingway. You can find many traces of his legacy around the town, including his former residence. The Hemingway House is open for tours, and you can see how the famous author spent his time in Key West

Main Cities You Will Pass Through

While on the road, there are plenty of nice and relaxing spots to park your RV. With this road trip itinerary from Fort Myers to Key West, you can find several clean and comfortable campgrounds for your vehicle. There are also a few dump stations along the way to help keep your rig sanitary throughout your journey. 


Fort Myers is located near the island of Sanibel. This beach paradise is known for its shell-filled beaches. The Sanibel Lighthouse dates back to the 19th century. Lighthouse Beach is a popular spot, and it features a boardwalk and fishing pier. For those nature lovers, you will want to visit the J.N. "Ding" Darling National Wildlife Refuge. With your RV, there are plenty of campgrounds around the Sanibel/Fort Myers area to spend the night. 

Coral Springs

Coral Springs is home to several historical attractions, including a 1965 bridge used to promote tourism in the area. Since the temperatures stay warm throughout the year, it is a popular spot for vacationers and RVers. You can find the perfect campground to meet your travel needs. 


You will not want to miss out on the fun and excitement of Miami. Throughout the city, you can enjoy upscale restaurants and world-class museums. For adults, many thrilling nightclubs come to life at the end of the day. However, there are also family-friendly activities at the Bayside Museum and Miami Seaquarium. Once you are ready to settle down for the night, you can find a couple of relaxing campgrounds throughout the Miami area, including the Miami Everglades RV Resort and the Hollywood KOA.

Find Adventure from Fort Myers to Key West

Find your One-Way Rental

You can stop and visit some of these exciting locations and historic spots as you complete your fun-filled trip through the Sunshine State. This Fort Myers to Key West road trip will make memories to last a lifetime. If you want to rent an RV, there is a large selection of vehicles available on our platform. With an RV, you can hit the road on your own terms. There is no need to make hotel reservations or search for restaurants. You can even choose to pick up your rental in Fort Myers or Key West. On your trip, you are protected with RVshare's 24/7 roadside assistance and nationwide insurance.